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Observe Intently (1)phenobarbital will lessen the extent or influence of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to a lower in fentanyl plasma concentrations, insufficient efficacy or, probably, enhancement of t